Hi Theodor, yes that is exactly what Easy FancyBox does.
It finds and binds to media links. The link can be formed with plain text or a thumbnail image, that does not matter. As long as the link points to a media file (which does not even have to be visible on the page, it just needs to live in the upload location where the link points to) and the plugin’s Autodetect feature should be able to pick it up 🙂